| Popis: |
Publisher Summary Individuals vary in their response to ionizing radiation. A proportion of individuals can suffer damage to normal tissues when exposed to standard doses. This chapter discusses three classes of such individuals: (1) those with an exaggerated acute response, the classical example being ataxia telangiectasia; (2) those with an exacerbated erythemal response; and (3) those that show untoward delayed responses. Ataxia telangiectasia patients are extremely rare, but their radiation management is relatively simple; they are managed by reducing applied doses by a factor of three. However, individuals with an exacerbated erythemal response and those who show untoward delayed responses are more difficult to quantify. The cellular radiosensitivity can be measured by using a number of end points with normal cells or tumor-derived cells. While clonal assays have been used for tumor-derived material, they are commonly used to measure the radiation response of normal tissues. |
