Thermodynamic and Spectroscopic Studies of Pentoxifylline in Aqueous Glucose/Lactose Solutions

Autor: Rajinder K. Bamezai, Shahid Shafi Shah, Taniya Sharma
Rok vydání: 2021
Předmět:
Zdroj: Journal of Solution Chemistry. 50:1363-1390
ISSN: 1572-8927
0095-9782
DOI: 10.1007/s10953-021-01123-1
Popis: The density, speed of sound and viscosity data of drug pentoxifylline in aqueous solutions of glucose (monosaccharide) and lactose (disaccharide) were determined. The various properties of the solutions were characterized and their structural features determined by varying the concentrations of solute and solvent at atmospheric pressure and at five different temperatures (293.15, 298.15, 303.15, 308.15 and 313.15) K. Infinite dilution limiting apparent molar volume ( $$V_{\phi }^{0}$$ ) and limiting apparent molar isentropic compression ( $$K_{\phi ,S}^{0}$$ ) parameters and their variation tendencies were considered in terms of the interactions between solute and solvent. The transfer parameters ( $$\Delta_{{{\text{tr}}}} V_{\phi }^{0}$$ and $$\Delta_{{{\text{tr}}}} K_{\phi ,S}^{0}$$ ) were positive and increased with increase in the concentrations of glucose/lactose in aqueous medium. Limiting apparent molar expansivity ( $$E_{\phi }^{0}$$ ), Hepler’s constant $$\left( {{{\partial^{2} V_{\phi }^{0} } \mathord{\left/ {\vphantom {{\partial^{2} V_{\phi }^{0} } {\partial T^{2} }}} \right. \kern-\nulldelimiterspace} {\partial T^{2} }}} \right)$$ and hydration number (nH) were also evaluated. The viscosity data have also been evaluated using the Jones–Dole equation. The results, analyzed using spectroscopic data, are discussed and rationalized in terms of various interactions.
Databáze: OpenAIRE
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