An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines

Autor:	Chad E. Stephens, Daniel P. Sweat, Steven M. Pochini, Nisaraporn Suthiwangcharoen
Rok vydání:	2011
Předmět:	Solvent Biphenyl chemistry.chemical_compound Chemistry Xantphos Ligand Stereochemistry Intramolecular force Organic Chemistry Polar effect Medicinal chemistry
Zdroj:	Journal of Heterocyclic Chemistry. 48:706-709
ISSN:	0022-152X
DOI:	10.1002/jhet.534
Popis:	A series of 4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position have been prepared by the palladium-catalyzed intramolecular N-arylation of some 2-aminopyrroles having a 2-bromobenzyl group at the N-1 position. Important for success of the reaction is the use of X-phos, a biphenyl mono-phosphine ligand, instead of xantphos, a more standard diphosphine ligand, and the use of t-BuOH as reaction solvent. J. Heterocyclic Chem., (2011).
Databáze:	OpenAIRE
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