Citric acid: A green cross-linker of biomaterials for biomedical applications
Autor: | Rabiu Salihu, Saiful Izwan Abd Razak, Mohammed Rafiq Abdul Kadir, Nurliyana Ahmad Zawawi, Norhana Jusoh, Mohd Riduan Mohamad, Nadirul Hasraf Mat Nayan, Norjihada Izzah Ismail |
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Rok vydání: | 2021 |
Předmět: |
Materials science
Polymers and Plastics Biocompatibility business.industry Organic Chemistry Cancer therapy General Physics and Astronomy Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Tissue engineering Compatibility (mechanics) Materials Chemistry 0210 nano-technology Citric acid business Cross linker Biomedicine |
Zdroj: | European Polymer Journal. 146:110271 |
ISSN: | 0014-3057 |
Popis: | The application of biomaterials in biomedicine currently suffers some drawbacks, such as inflammation and immunological responses due to mismatching and/or limited compatibility. Biomaterials that are cross-linked with citric acid (CA), also called citrate-based biomaterials (CBBs), have exhibited advanced in-vitro and in-vivo material properties that make them suitable for various biomedical applications. Tunable mechanical properties, biocompatibility, and biofunctionality are among other factors that make CBBs interesting in this field. To emphasize the safety and greenness nature of CA, in this review, we have highlighted the history, potential considerations of exploration, and a summarized stage-wise criterion for developing CBBs. We also discuss several points of view about the application of CA and CBBs in many different aspects of biomedicine, such as in tissue engineering, cancer therapy, and wound dressings. |
Databáze: | OpenAIRE |
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