Dual-Mode Avocado-like All-Iron Nanoplatform for Enhanced T1/T2 MRI-Guided Cancer Theranostic Therapy
| Autor: | Xincong Li, Siman Gong, Hongzhi Qiao, Chenggen Qian, Minjie Sun, Cuiting Zhang, Jing Li |
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| Rok vydání: | 2020 |
| Předmět: |
Combination therapy
business.industry Mechanical Engineering Dual mode Cancer Bioengineering 02 engineering and technology General Chemistry Photothermal therapy 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease Heat generation Drug delivery Coordination network Medicine General Materials Science Doxorubicin 0210 nano-technology business Biomedical engineering medicine.drug |
| Zdroj: | Nano Letters. 20:4842-4849 |
| ISSN: | 1530-6992 1530-6984 |
| DOI: | 10.1021/acs.nanolett.0c00817 |
| Popis: | Development of T1/T2 dual-mode MRI contrast agents that can also treat cancer is an attractive prospect for personalized precision medicine. Unfortunately, conventional contrast agents can suffer from toxicity and lack any ability to treat cancer. An all-iron T1/T2 MR imaging agent with photothermal and drug delivery capability would overcome these issues. Here, an avocado-like Fe3+/Fe2O3 composed T1-T2 dual-mode contrast agent based on Fe-TA coordination network (CNMN) is developed. This material possesses suitable longitudinal and transverse relaxation coefficients. Moreover, the strong heat generation property of Fe-TA endows CNMN with the capability to act as a potent photothermal agent. Furthermore, CNMN can also act as an effective delivery platform for the chemotherapeutic drug doxorubicin (DOX) to achieve high effective chemo-photothermal combination therapy. The work demonstrates reliable T1-T2 MRI-guided chemo-photothermal therapy for safe and effective clinical application. |
| Databáze: | OpenAIRE |
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