Synthesis and Biological Evaluation of α-L-Fucosidase Inhibitors: 5a-Carba-α-L-fucopyranosylamine and Related Compounds

Autor:	Takashi Odagiri, Hironobu Hashimoto, Hideya Yuasa, Ayako Maruyama, Seiichiro Ogawa
Rok vydání:	2001
Předmět:	Stereochemistry Organic Chemistry α l fucosidase Validamine Inhibitory postsynaptic potential chemistry.chemical_compound Biochemistry chemistry Amine gas treating Glycoside hydrolase Fucopyranosylamine Physical and Theoretical Chemistry Lead compound Biological evaluation
Zdroj:	European Journal of Organic Chemistry. 2001:967-974
ISSN:	1099-0690 1434-193X
DOI:	10.1002/1099-0690(200103)2001:5<967::aid-ejoc967>3.0.co;2-j
Popis:	5a-Carba-α-L-fucopyranosylamine (5), an α-glucosidase inhibitor validamine analog possessing an α-L-fucose-type structure, and four related compounds (4 and 6−8) were synthesized and their glycosidase inhibitory potential determined. Carbafucosylamine has already been shown to possess a specific and very strong inhibitory activity against α-L-fucosidase (Ki = 1.2 × 10−8M, bovine kidney). Judging from the activity of the other analogs prepared, this amine might be expected to be a lead compound for development of a new type of α-L-fucosidase inhibitor.
Databáze:	OpenAIRE
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