Nanotherapeutic potential of antibacterial folic acid-functionalized nanoceria for wound-healing applications
| Autor: | Kunal Sarkar, Kaushik Dutta, Arindam Chatterjee, Jit Sarkar, Dipankar Das, Arbind Prasad, Dipankar Chattopadhyay, Krishnendu Acharya, Madhusudan Das, Suresh K Verma, Sriparna De |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Nanomedicine. 18:109-123 |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2022-0233 |
| Popis: | Aim: The functionalization and characterization of antibacterial nanoceria with folic acid (FA) and elucidation of their in vivo wound-healing application. Materials & methods: Functionalization of nanoceria were done with FA using a chemical method and their antibacterial activity, cellular biocompatibility and in vivo wound-healing application were evaluated. Results: The functionalization of nanoceria with FA was done with 10–20 nm size and -20.1 mV zeta potential. The nanoformulation showed a bacteriostatic effect along with biocompatibility to different cell lines; 0.1% w/v spray of FA-nanoceria demonstrated excellent wound-healing capacity within 14 days in a Wister rat model. Conclusion: The antioxidant and reactive oxygen species scavenging activity of the FA-nanoceria make it a promising therapeutic agent as a unique spray formulation in wound-healing applications. |
| Databáze: | OpenAIRE |
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