| Popis: |
Xenobiotics that mimic or obstruct endocrine function in vertebrates and affect the function of a wide variety of physiological systems including reproduction, immunity, osmoregulation, development, and growth are termed endocrine disrupting chemicals (EDCs). EDCs are a structurally diverse group of natural and anthropogenic compounds, and so general conclusions regarding the toxicokinetics of EDCs are difficult to make. This chapter focuses on xenoestrogens, EDCs that affect estrogen-responsive systems. Effects are brought about by binding to nuclear or membrane estrogen receptors, other receptors in the nuclear hormone receptor superfamily, through crosstalk with other receptor-mediated signaling systems, and nonreceptor mediated mechanisms. |
