Common and Rare Genetic Variants Associated With Alzheimer's Disease
| Autor: | Jaana Suhonen, Mohammad A. Al-Banna, Hany E. Marei, Thomas Caceci, Mohamed E. El Zowalaty, Tengfei Wang, Carlo Cenciarelli, Asmaa Althani |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Genetics Physiology Clinical Biochemistry Single-nucleotide polymorphism Genome-wide association study Cell Biology Disease Biology medicine.disease Genome Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Alzheimer's disease 030217 neurology & neurosurgery Exome sequencing Genetic association |
| Zdroj: | Journal of Cellular Physiology. 231:1432-1437 |
| ISSN: | 0021-9541 |
| DOI: | 10.1002/jcp.25225 |
| Popis: | Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome-wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD-related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets. |
| Databáze: | OpenAIRE |
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