Successful induction of immune tolerance in a patient with haemophilia B with inhibitor
| Autor: | Tsukasa Hori, J. Watanabe, Nobuo Mizue, Hiroyuki Tsutsumi, Tooru Kudoh, Naoki Hatakeyama, Nobuhiro Suzuki, Takanori Oda |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
business.industry Intracranial haemorrhage Low dose Hematology General Medicine medicine.disease Haemophilia Gastroenterology Immune tolerance Surgery Internal medicine medicine Haemophilia B business Nephrotic syndrome Genetics (clinical) Factor IX medicine.drug Prophylactic treatment |
| Zdroj: | Haemophilia. 9:340-342 |
| ISSN: | 1351-8216 |
| DOI: | 10.1046/j.1365-2516.2003.00754.x |
| Popis: | Summary. We describe successful induction of immune tolerance (IT) in a 10-month-old boy with severe haemophilia B. Urticaria developed soon after starting prophylactic treatment and was associated with an inhibitor at 7 Bethesda units mL−1. Initially, we tried low dose factor IX therapy to induce IT with only a transient effect. The patient experienced an intracranial haemorrhage. A simple bolus dose of FIX eradicated the inhibitor. Thereafter he has been free from inhibitor and nephrotic syndrome for more than 5 years, although he receives FIX three times a week. |
| Databáze: | OpenAIRE |
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