The Influence of Social Isolation and Enriched Environment on Fear Conditioning in Rats after Early Proinflammatory Stress
| Autor: | N. D. Broshevitskaya, I. V. Pavlova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Environmental enrichment Physiology business.industry Post conditioning Context (language use) Extinction (psychology) Contextual fear Biochemistry Proinflammatory cytokine Endocrinology Internal medicine medicine Fear conditioning Social isolation medicine.symptom business Ecology Evolution Behavior and Systematics |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 57:803-816 |
| ISSN: | 1608-3202 0022-0930 |
| Popis: | The effect of social isolation or enriched environment on fear conditioning and extinction was studied in 3.5–4-month-old rats exposed to early proinflammatory stress via LPS administration on the 3rd and 5th day after birth. Social isolation reduced the expression of conditioned fear in males and females, as measured by a decrease in time of the freezing response 24 h post conditioning. The greatest sensitivity to social isolation was observed in rats with early proinflammatory stress, for which the freezing time was reduced after exposure to both the cue and the context. We hypothesize that the decrease in fear is associated with a memory deficit. The enriched environment also reduced the freezing time, but to a lesser extent than social isolation, and only the contextual fear response was reduced. The extinction of fear in males of the LPS group was accelerated after exposure to social isolation and enriched environment compared to animals of this group kept in standard conditions. Exposure to early proinflammatory stress resulted in an increased vulnerability of adult animals to changes in housing conditions. |
| Databáze: | OpenAIRE |
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