Synthesis of Macrocycles Containing 1,2,3-Triazole Motifs

Autor:	Pavel Hradil, Martin Grepl, Antonín Lyčka, Ludmila Hradilová, Jan Hlaváč
Rok vydání:	2012
Předmět:	chemistry.chemical_classification 1 2 3-Triazole Carboxylic acid Organic Chemistry Alkyne Alkylation Combinatorial chemistry Catalysis Cycloaddition Ring size chemistry.chemical_compound chemistry Organic chemistry Propargyl bromide Azide
Zdroj:	Synthesis. 44:1398-1404
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0031-1290760
Popis:	A new procedure for the preparation of macrocycles containing 1,2,3-triazole motifs is developed. The macrocyclic precursor is constructed by repetition of a series of steps which include cycloaddition of an azide with an alkyne, alkylation of a carboxylic acid with propargyl bromide and formation of an azide from an amino group. The order of the steps and the size of the connected fragments are determined by the desired ring size. Chromatographic purification techniques for the poorly soluble final products are also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1ba9543e4704a44dfcdd88bb8940d723 https://doi.org/10.1055/s-0031-1290760 Zobrazit plný text záznamu