| Popis: |
There is an increasing awareness of the importance of essential trace metals, particularly zinc and copper, in normal cell growth and development [1]. Central to this theme has been the postulated direct involvement of zinc in the control of gene expression [2]. A number of zinc metalloproteins have been reported to be involved in replication and transcription, including RNA and DNA polymerases [3]. Thus, the question arises as to the mechanism by which the activity of these enzymes might be directly regulated by cytosolic trace metals. |
