Contributions of Procalcitonin in the Treatment of Neonatal Late Onset Sepsis: A Prospective Observational Study
| Autor: | Mohamed Ali Lachtar, Laurence Foix L'Helias, Aude du Mesniladelee, Inès de Montgolfier, Delphine Mitanchez, V. Champion, François Kieffer |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pediatrics medicine.diagnostic_test biology Central Line Infection medicine.drug_class business.industry C-reactive protein Antibiotics Antimicrobial Procalcitonin 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine medicine biology.protein Blood culture Observational study 030212 general & internal medicine Neonatology business |
| Zdroj: | Journal of Pregnancy and Child Health. 3 |
| ISSN: | 2376-127X |
| DOI: | 10.4172/2376-127x.1000256 |
| Popis: | Background: Duration of antibiotic treatment in neonatal late onset sepsis is empirical. Objectives: a) To study the evolution of procalcitonin during treatment of secondary sepsis in new-borns, b) To evaluate the reduction of antibiotic exposure using its serial measurements. Methods: This single-center prospective observational study was conducted in a level II neonatology unit in the Armand Trousseau Hospital in Paris, France. All neonates hospitalized in the unit between December 2011 and January 2013 with suspected infection after 5 days of life and serum procalcitonin concentration >0.6 μg/L were included. Serial procalcitonine, C-reactive protein and blood culture survey was performed during antimicrobial therapy. Antimicrobial therapy was administered for 10 days after the last positive blood culture. Results: 54 infective episodes were observed in 46 neonates, born at a mean term of 32 weeks (range: 26-40) and infected at mean age of 19 days (7-40). Staphylococci was found in 31 infective episodes (57.4%), other microorganisms in 12 (22.2%), and none bacteria in 11 episodes (20.4%). The main cause was central line infection (85.2%). On day 5, 80% of procalcitonin measurements were |
| Databáze: | OpenAIRE |
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