In Vitro Cytotoxic Activity of Isostichopus badionotus, a Sea Cucumber from Yucatan Peninsula Coast
| Autor: | Jaqueline Canul-Canche, Catalina Rivas-Morales, María Eufemia Morales-Rubio, Aida R. Pérez-Espadas, Azucena Oranday-Cárdenas, Leovigildo Quijano, Lorena V. León-Deniz, María Julia Verde-Star |
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| Rok vydání: | 2014 |
| Předmět: |
Nutrition and Dietetics
Health (social science) Butanol Ethyl acetate Medicine (miscellaneous) Biology biology.organism_classification Molecular biology In vitro Hexane HeLa chemistry.chemical_compound Sea cucumber chemistry Biochemistry Cytotoxic T cell Isostichopus badionotus General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Journal of Pharmacy and Nutrition Sciences. 4:183-186 |
| ISSN: | 1927-5951 2223-3806 |
| DOI: | 10.6000/1927-5951.2014.04.03.3 |
| Popis: | The in vitro cytotoxic activity of hexane, ethyl acetate and butanol extracts of the sea-cucumber Isostichopus badionotus (Holothuroidea) was tested against normal cells (Vero), human cervical carcinoma (HeLa) and breast adenocarcinoma (MCF-7 and MDA-MB-231) ATCC cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Hexane extracts from body walls and viscera showed high cytotoxic activity against HeLa cells (IC50’s = 48.5 and 42.5 µg mL-1, respectively), while the ethyl acetate extract of body walls was considered low active (IC50 = 98.3 μg mL-1). In addition, the body walls hexane extract showed a good selectivity index value of 12.0. |
| Databáze: | OpenAIRE |
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