Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island

Autor: Il-Chan Kim, Seul Ki Min, Ui Joung Youn, Jung Eun Kim, Se Jong Han, Ju-Mi Hong, Hyun Park, Joung Han Yim
Rok vydání: 2020
Předmět:
Zdroj: Biotechnology and Bioprocess Engineering. 25:543-550
ISSN: 1976-3816
1226-8372
DOI: 10.1007/s12257-019-0371-4
Popis: Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1s and 1α (IL-6, IL-1s and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.
Databáze: OpenAIRE
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