| Popis: |
Recombinant inbred (RI) strains are widely used to identify gene variants and genetic and molecular networks underlying individual differences in behavioral pharmacology. In this contribution, we describe our previously published work in the application of RI strains to elucidate individual differences in cocaine-related behaviors and related dopamine neurochemistry. In this earlier work, we administered four doses of cocaine to male and female BXD RI strains and measured effects on locomotor activity, nose pokes, rearing, and time spent in the center of an open field. We also measured densities of dopamine receptors in several brain regions. These data were integrated on Genenetwork.org to identify possible candidate genes and to examine linkages among phenotypes. In this introduction to genetic analysis, we present an overview and insight into how to use data sets in GeneNetwork to develop new hypotheses on the genetic and mechanistic linkages between behavior, molecular pharmacology, and causal sequence variants. |
