Cytotoxicity of Pure Nanodrugs of SN-38 and Podophyllotoxin Dimers in Human Cancer HepG2, KPL-4, and MCF-7 Cells

Autor:	Tatsuya Murakami, Liman Cong, Yoshikazu Ikuta, Hitoshi Kasai, Tsunenobu Onodera, Yoshitaka Koseki, Hidetoshi Oikawa, Noriaki Ohuchi, Kohsuke Gonda, Hiroshi Tada
Rok vydání:	2015
Předmět:	Stereochemistry Dimer SN-38 General Chemistry Condensed Matter Physics chemistry.chemical_compound Podophyllotoxin chemistry MCF-7 medicine General Materials Science Drug nanoparticles Cytotoxicity Human cancer medicine.drug Nuclear chemistry
Zdroj:	Molecular Crystals and Liquid Crystals. 622:1-5
ISSN:	1563-5287 1542-1406
Popis:	Pure nanodrugs (PNDs) is a newly designed drug materials, which is a carrier-free drug nanoparticles fabricated by the reprecipitation method. In the present study, the cytotoxicity of PNDs consisting of SN-38 dimer and podophyllotoxin dimer with size in the range 30–50 nm was evaluated in human cancer HepG2, KPL-4, and MCF-7 cells. It was observed that the cytotoxicities of PNDs were changed depending on the type of cells. In addition, PNDs coated with polysorbate 80 showed higher activity than free PNDs, which suggests that the surface state of PNDs was the one of the important factors to affect cytotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1ba1910f79e5b10b984d7fe0c4f386d0 https://doi.org/10.1080/15421406.2015.1096483 Zobrazit plný text záznamu