| Autor: |
Jan Milecki, Ryszard W. Adamiak, Artur Fischer, Marek Łożyński, Ewa Biala, Zofia Gdaniec |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Nucleosides and Nucleotides. 15:477-488 |
| ISSN: |
0732-8311 |
| DOI: |
10.1080/07328319608002399 |
| Popis: |
Results of PM3 semiempirical calculation revealed that energy and hydrogen bonds geometry of 1-methyl-5-fluoro-uracil and -cytosine base-pairs with 9-methyl-adenine and -guanine respectively are virtually the same as for the natural bases. Analysis of proton coupling constants proved that the sugar puckering of 5-fluorouridine and 5-fluorocytidine is analogous to non-modified ribonucleosides. 5-Fluorocytidine was regioselectively introduced to oligoribonucleotides, prepared using 2′-O-tert-dimethylsilyl protection, via post-synthetic quantitative ammonolysis of 4-O-methyl-5-fluorouridine derived precursor. #Dedicated to Professor Yoshihisa Mizuno on the occasion of his 75th birthday. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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