Metal complexes of radiosensitization drugs: the characterization of the metronidazole adducts of dirhodium(II)tetracarboxylate compounds

Autor:	Elizabeth C. Morrison, Leslie D. Dale, David I. Edwards, T. M. Dyson, Derek A. Tocher
Rok vydání:	1990
Předmět:	Addition reaction Chemistry Stereochemistry Crystal structure Electrochemistry Medicinal chemistry Adduct Inorganic Chemistry Metal chemistry.chemical_compound visual_art X-ray crystallography Materials Chemistry visual_art.visual_art_medium Molecule Carboxylate Physical and Theoretical Chemistry
Zdroj:	Inorganica Chimica Acta. 169:127-131
ISSN:	0020-1693
Popis:	The compounds Rh 2 (O 2 CR) 4 ·2metronidazole (R = CH 3 (1); CH 2 CH 2 CH 2 Ph (2)) have been prepared by the reaction of Rh 2 (O 2 CR) 4 with an excess of metronidazole. The compounds have been characterized by analytical, spectroscopic, electrochemical and crystallographic measurements. Preliminary biological studies, on 1 , have shown the compound to have selective toxic effects on DNA and intact cells under both anoxic and hypoxic conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b9dafa2c03bcccb19fb41dae59ffc71 https://doi.org/10.1016/s0020-1693(00)82045-9 Zobrazit plný text záznamu