HER2/neu Expression in Oral Squamous Cell Carcinoma

Autor:	Satoru Shintani, Chunnan Li, Hiroyuki Hamakawa, Yuuji Nakahara, Mariko Mihara, Koh-ichi Nakashiro
Rok vydání:	2004
Předmět:	Pathology medicine.medical_specialty biology business.industry HER2/neu stomatognathic diseases Cell culture Molecular targets medicine biology.protein Immunohistochemistry Orthopedics and Sports Medicine Surgery Basal cell Oral Surgery Antibody skin and connective tissue diseases business
Zdroj:	Asian Journal of Oral and Maxillofacial Surgery. 16:172-176
ISSN:	0915-6992
DOI:	10.1016/s0915-6992(04)80028-1
Popis:	Objective: To evaluate the expression of HER2/neu in oral squamous cell carcinoma with a view to determining the usefulness of molecular target therapy by anti-HER2 antibody. Patients and Methods: Oral squamous cell carcinoma cell lines and 69 clinical tumour samples were tested using enzyme-linked immunosorbent assay and immunohistochemistry. Positive and negative controls were utilised. Results: Expression of HER2/neu in oral squamous cell carcinoma cell lines was low. Overexpression was not observed in the clinical samples. Conclusion: Low prevalence of expression of HER2/neu in oral squamous cell carcinoma limits the likely utility of herceptin therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b9aff2c403d752c4948699c4d62e789 https://doi.org/10.1016/s0915-6992(04)80028-1 Zobrazit plný text záznamu Full Text from ScienceDirect