Palladium-catalyzed sequential indole synthesis using sterically hindered amines
| Autor: | Mikhail V. Kondrashov, Lutz Ackermann, Marvin Schinkel, René Sandmann |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
inorganic chemicals
Intramolecular reaction 010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Chemical synthesis 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Intramolecular force Drug Discovery Hydroamination Carbene Amination Palladium |
| Zdroj: | Tetrahedron. 65:8930-8939 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2009.07.073 |
| Popis: | A palladium catalyst derived from a bulky N-heterocyclic carbene ligand enabled a modular synthesis of indoles bearing sterically hindered N-alkyl or N-aryl substituents through a reaction sequence comprising an intermolecular N-arylation and an intramolecular hydroamination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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