Recovery of Hibernating Myocardium: What Is the Role of Surgical Revascularization?
| Autor: | Edward O. McFalls, E B S Megan Lindsey, Eric K. Long, Rosemary F. Kelly, Christopher T. Holley |
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| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac function curve Hibernating myocardium medicine.medical_specialty Myocardial revascularization business.industry medicine.medical_treatment Ischemia medicine.disease Revascularization Surgery Antioxidant capacity Internal medicine Cardiology Medicine medicine.symptom Cardiology and Cardiovascular Medicine business Heart metabolism Surgical revascularization |
| Zdroj: | Journal of Cardiac Surgery. 30:224-231 |
| ISSN: | 0886-0440 |
| Popis: | Myocardial responses to chronic ischemia represent a continuum of adaptations resulting, over time, in a stress-resistant phenotype. One such adaptation, hibernating myocardium (HM), has increased antioxidant capacity that protects against ischemia-induced oxidative stress. Studies have suggested that revascularization alone may not fully restore cardiac function, highlighting the need for targeted therapies to serve as adjuncts to the innate healing process following revascularization. In our review, we discuss current understanding of HM and the recovery process following surgical revascularization, focusing on animal models of HM to understand implications for human patients. |
| Databáze: | OpenAIRE |
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