Syntheses of [14C]-detergents: octaethylene-glycol-[1-14C]-dodecylether, [1-14C]-dodecyl-β-D -maltoside and dibromo-analogues
| Autor: | Jean Pierre Noël, Marc le Maire, Dominique Georgin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Organic Chemistry Disaccharide Halogenation Glycoside Biochemistry Chemical synthesis Oligomer Medicinal chemistry Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery Radiology Nuclear Medicine and imaging Aliphatic compound Spectroscopy N dodecyl β d maltoside |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 44:575-585 |
| ISSN: | 0362-4803 |
| Popis: | Octaethylene-glycol-dodecylether and dodecyl-β-D-maltoside are two widely used detergents in membrane protein studies. We describe here the synthesis of the 14C-labelled brominated analogues, and of the 14C-labelled forms. [1-14C]-5,6-Dibromo-dodecylether was prepared by coupling [1-14C]-(Z)-1-bromo-dodec-5-ene with octaethylene glycol followed by bromination. [1-14C]-5,6-Dibromo-dodecyl-β-D-maltoside was synthesised from [1-14C]-(Z)-dodec-5-en-l-ol via a coupling with α-bromohepta-O-acetyl-maltose followed by a deprotection step and bromination. Following similar methods, octaethylene-glycol-[1-14C]-dodecylether and [1-14C]-dodecyl-β-D-maltoside were also obtained. Copyright © 2001 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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