| Popis: |
Currently, the fight against cancer diseases and the development of the noninvasive and less harmless methods of its treatment are among the most pressing issues. In this context, magnetic hyperthermia (MHT) is one of the promising and safe methods with the local effect and is gradually being introduced into world medical practice. This chapter presents various ideas and approaches to self-controlled MHT based on the use of complex magnetic oxide nanoparticles. To begin with, we expose the methods and conditions of synthesis of magnetic nanoparticles with the spinel and perovskite structures, such as cryochemical method, precipitation in microemulsions and nonaqueous solutions, hydroxide precipitation, and solgel method. We then turn to the research outcome for the materials requiring external temperature control as well as for those with its automatic preset when used in MHT on the example of nanoparticles of ferrimagnetic spinel and lanthanum–strontium manganites. Experimental aspects are reviewed in the next sections, constructed according to material and sample types, explaining the special role played by the characteristic parameters of magnetic nanoparticles (saturation magnetization, the effective magnetic anisotropy constant, the coercivity, the volume of the magnetic nanoparticle (MNP) and the relaxation time of the MNPs system) and external parameters (the frequency of the external magnetic field and temperature) in the processes of nanoparticles remagnetization and thus in their behavior as heat mediators of magnetic hyperthermia. Also there considered in vitro and in vivo biomedical studies of the magnetic fluids based on the lanthanum–strontium manganite nanoparticles which have been investigated only episodically by this time. The authors try to provide a unified view of the vast research on the subject and the basic unresolved issues together with the remaining challenges in the way of wide MHT application. |
