The chloromethylation of codeine. Isolation of a quaternary iodide

Autor:	Linda M. Mascavage, Andrew D. Grant, George E. Kemmerer, David R. Dalton, David E. Zacharias
Rok vydání:	1993
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Polycyclic compound Chemistry Alkaloid Organic Chemistry Iodide Nuclear magnetic resonance spectroscopy Crystal structure Carbon-13 NMR Chloroiodomethane Medicinal chemistry Dichloromethane
Zdroj:	Journal of Heterocyclic Chemistry. 30:553-557
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570300250
Popis:	A single N-chloromethylcodinium iodide has been isolated from the reaction of chloroiodomethane with codeine. Complete proton and carbon nmr and X-ray analyses dictate that this stable material bears the chloromethyl group axial. It is identical (except for the anion) to one of the salts obtained on long term storage of codeine in dichloromethane
Databáze:	OpenAIRE
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