Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
| Autor: | Norra Harun, Saad M. Al-Shibli, Muna Kh. Al-kubaisi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Leptin receptor Colorectal cancer business.industry Leptin digestive oral and skin physiology Population medicine.disease digestive system diseases Endocrinology Internal medicine medicine Immunohistochemistry Adenocarcinoma education business Receptor hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | International Journal of Innovative Research in Medical Science. 5 |
| ISSN: | 2455-8737 |
| DOI: | 10.23958/ijirms/vol05-i02/849 |
| Popis: | Objectives: To assess the role of leptin in human colonic adenocarcinoma and to establish its expression in Malay population patients by using immunohistochemistry study. Methodology: Immunohistochemical study (IHC) using antibodies against leptin and its receptor was applied to assess the expression of leptin and its receptor in 38 samples of adenocarcinoma of the colon among Malay population and compare this expression with that of the adjacent normal colon tissue. Results: All the 38 colon adenocarcinoma samples stained strongly (100%) for leptin and 36 out of 38 also stained strongly for leptin receptor (95%). The other 2 (5%) stained weak (1+). However, the whole specimens of the normal adjacent colon tissue stained weakly (1+) for both leptin and leptin receptor. The expression of both hormones in cancer and normal tissue is significantly different (p |
| Databáze: | OpenAIRE |
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