A Controlled Trial of Fish Oil in IgA Nephropathy

Autor: James V. Donadio, Erik J. Bergstralh, Dorothy C. Spencer, Kenneth P. Offord, Keith E. Holley
Rok vydání: 1994
Předmět:
Zdroj: New England Journal of Medicine. 331:1194-1199
ISSN: 1533-4406
0028-4793
DOI: 10.1056/nejm199411033311804
Popis: Background The n-3 fatty acids in fish oil affect eicosanoid and cytokine production and therefore have the potential to alter renal hemodynamics and inflammation. The effects of fish oil could prevent immunologic renal injury in patients with IgA nephropathy. Methods In a multicenter, placebo-controlled, randomized trial we tested the efficacy of fish oil in patients with IgA nephropathy who had persistent proteinuria. The daily dose of fish oil was 12 g; the placebo was a similar dose of olive oil. Serum creatinine concentrations, elevated in 68 percent of the patients at base line, and creatinine clearance were measured for two years. The primary end point was an increase of 50 percent or more in the serum creatinine concentration at the end of the study. Results Fifty-five patients were assigned to receive fish oil, and 51 to receive placebo. According to Kaplan-Meier estimation, 3 patients (6 percent) in the fish-oil group and 14 (33 percent) in the placebo group had increases of 50 percent or more i...
Databáze: OpenAIRE