A Controlled Trial of Fish Oil in IgA Nephropathy
Autor: | James V. Donadio, Erik J. Bergstralh, Dorothy C. Spencer, Kenneth P. Offord, Keith E. Holley |
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Rok vydání: | 1994 |
Předmět: |
Nephrology
medicine.medical_specialty Creatinine business.industry Renal function General Medicine medicine.disease Fish oil Placebo Gastroenterology Nephropathy law.invention chemistry.chemical_compound Endocrinology Randomized controlled trial chemistry law Internal medicine medicine Clinical endpoint business |
Zdroj: | New England Journal of Medicine. 331:1194-1199 |
ISSN: | 1533-4406 0028-4793 |
DOI: | 10.1056/nejm199411033311804 |
Popis: | Background The n-3 fatty acids in fish oil affect eicosanoid and cytokine production and therefore have the potential to alter renal hemodynamics and inflammation. The effects of fish oil could prevent immunologic renal injury in patients with IgA nephropathy. Methods In a multicenter, placebo-controlled, randomized trial we tested the efficacy of fish oil in patients with IgA nephropathy who had persistent proteinuria. The daily dose of fish oil was 12 g; the placebo was a similar dose of olive oil. Serum creatinine concentrations, elevated in 68 percent of the patients at base line, and creatinine clearance were measured for two years. The primary end point was an increase of 50 percent or more in the serum creatinine concentration at the end of the study. Results Fifty-five patients were assigned to receive fish oil, and 51 to receive placebo. According to Kaplan-Meier estimation, 3 patients (6 percent) in the fish-oil group and 14 (33 percent) in the placebo group had increases of 50 percent or more i... |
Databáze: | OpenAIRE |
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