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The glutathione S-transferases (GSTs) are a family of proteins that conjugate glutathione, via the sulfur atom of cysteine, to various electrophiles (Boyland and Chasseaud 1969; Chasseaud 1979; Jacoby 1978; Mannervik 1985; Mannervik and Danielson 1988; Pickett and Lu 1989; Coles and Ketterer 1990; Armstrong 1991; Tsuchida and Sato 1992). In addition to the conjugation of electrophiles, the GSTs bind with high affinity a variety of hydrophobic compounds such as heme, bilirubin, polycyclic hydrocarbons, and dexamethazone (Litwack et al. 1971; Arias et al. 1976; Bhargava et al. 1980; Homma a n d Listowsky 1985). |
