Clinical pharmacokinetic-pharmacodynamic (PK/PD) modeling study of the novel dual PI3K/mTOR inhibitor BEZ235

Autor:	Vincent Duval, Johanna C. Bendell, H. A. Burris, D. Bottino, Carolyn D. Britten, C. Sarr, Lisa Chen, O. Chiparus, J. Tabernero, J. Rodon Ahnert, E. di Tomaso, Wolfgang Hackl, J. Baselga
Rok vydání:	2011
Předmět:	Cancer Research business.industry Pharmacology Discovery and development of mTOR inhibitors Clinical pharmacokinetic PI3K/mTOR Inhibitor BEZ235 Oncology Antiangiogenic effect Apoptosis Pharmacodynamics Medicine business PK/PD models PI3K/AKT/mTOR pathway
Zdroj:	Journal of Clinical Oncology. 29:3056-3056
ISSN:	1527-7755 0732-183X
Popis:	3056 Background: BEZ235 is a novel pan-class I PI3K/mTOR inhibitor with proven apoptotic effect (Brachman et al 2009), antiangiogenic effect (Schnell et al 2009) and clinical activity especially in...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b5f9f1408640d901c2d7f06aa36ea53 https://doi.org/10.1200/jco.2011.29.15_suppl.3056 Zobrazit plný text záznamu