| Autor: |
Asmaa F Sharif, Zeinab A Kasemy, Rakan A Alshabibi, Salem J Almufleh, Fahad W Abousamak, Abdulmajeed A Alfrayan, Muath Alshehri, Rakan A Alemies, Assim S Almuhsen, Shahd N AlNasser, Khalid A Al-Mulhim |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Toxicology Research. 12:62-75 |
| ISSN: |
2045-4538 |
| Popis: |
BackgroundAcute intoxication with central nervous system (CNS) xenobiotics is an increasing global problem. Predicting the prognosis of acute toxic exposure among patients can significantly alter the morbidity and mortality. The present study outlined the early risk predictors among patients diagnosed with acute exposure to CNS xenobiotics and endorsed bedside nomograms for identifying patients requiring intensive care unit (ICU) admission and those at risk of poor prognosis or death.MethodsThis study is a 6-year retrospective cohort study conducted among patients presented with acute exposure to CNS xenobiotics.ResultsA total of 143 patients’ records were included, where (36.4%) were admitted to the ICU, and a significant proportion of which was due to exposure to alcohols, sedative hypnotics, psychotropic, and antidepressants (P = 0.021). ICU admission was associated with significantly lower blood pressure, pH, and HCO3 levels and higher random blood glucose (RBG), serum urea, and creatinine levels (P ConclusionThe proposed nomograms yielded significant straightforward and reliable prognostic outcomes predictors in acute exposure to CNS xenobiotics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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