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Background evaluation of influence of beta-blocker (bisoprolol) on clinical indicators and heart rate variability in children with rhythm disturbances and mitral valve prolapse (MVP). Material and methods The carried out research has included 50 children, with mitral valve prolapse and rhythm disorders : I group (bisoprolol) 30 (60,0%) children, average age (12,90±0,53) years and II group (placebo) 20 (40,0%) children, average age (13,5±0,60) years, doses of bisoprolol (PO): 1,25–2,5 mg/kg/dose with inspection of haemodynamic and heart rate variability indicators, who were examined with ECG, echocardiography, ECG Holter monitoring over 24 hours, and monitoring blood pressure over 24 hours. Results The analysis of haemodynamic parametres has revealed, that bisoprolol has not changed average values of systolic and dyastolic blood pressure in the first group in the beginning of research and in dynamics a month later, in comparison with the second group (p>0,05). At patients with MVP, bisoprolol has lowered number of heart rate reductions (−8,9) in dynamics a month later in comparison with placebo (p 0,05), but has lowered the maximum values of heart rate reductions at children with MVP (−8,74; p 0,05) and average values of heart rate (−4,70; p 0,05). Statistical parametres HRV (SDNN and PNN 50) defined in the beginning in both groups did not differ considerably (p>0,05). Dynamics in a month of action bisoprolol on indicators HRV was showed by decrease in value PNN 50 in the first group (−6,42; p Conclusions results of research have revealed, that at children with symptomatic mitral valve prolapse, bisoprolol has considerably reduced heart rate (−8,9; p |
