Abnormalities of Serum Anti-Elastin Antibodies in Patients with Polymyalgia Rheumatica

Autor:	Euly Langga-Shariffi, Marilyn C. Malto, Lawrence B. Sandberg, Keith K. Colburn, Lora M. Green
Rok vydání:	2006
Předmět:	musculoskeletal diseases Pathology medicine.medical_specialty integumentary system biology Tropoelastin business.industry Osteoarthritis medicine.disease Pathogenesis Polymyalgia rheumatica Giant cell arteritis Rheumatology medicine biology.protein In patient Antibody business Elastin
Zdroj:	Journal of Musculoskeletal Pain. 14:21-26
ISSN:	1540-7012 1058-2452
Popis:	Background: Antibodies [Abs] to alpha-elastin [elastin breakdown product] and tropoelastin [elastin precursor] are found in serum of all human subjects and correlate with their respective serum peptide levels. Serum elastin peptide levels vary with age and some disease states. Vascular damage is thought to be a possible mechanism in the pathogenesis of polymyalgia rheumatica [PMR] and in the closely related condition of giant cell arteritis. Damage to elastin is a characteristic of giant cell arteritis. This study was undertaken to determine if the levels of serum Abs against elastin were altered in patients with PMR by measuring the ratio of serum anti-alpha elastin to anti-tropoelastin Abs compared to age matched controls.Methods: Sera from 37 elderly patients with PMR were compared with sera from 45 age-matched, otherwise healthy osteoarthritis subjects using an enzyme-linked immunosorbent assay that measured levels of anti-alpha and anti-tropoelastin Abs.Results: We found a decrease in anti-tropoelast...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b427119df6c334411eb238055192bb7 https://doi.org/10.1300/j094v14n03_04 Zobrazit plný text záznamu Plný text ve formátu PDF