ChemInform Abstract: Carbonyl-Assisted Reverse Regioselective Cascade Annulation of 2-Acetylenic Ketones Triggered by Ru-Catalyzed C-H Activation

Autor:	Nagendra Govindappa, Rambabu Chegondi, Shivakrishna Kallepu, Krishna Kumar Gollapelli, Jagadeesh Babu Nanubolu
Rok vydání:	2016
Předmět:	chemistry.chemical_classification Annulation Aryl Alkyne Regioselectivity chemistry.chemical_element General Medicine Combinatorial chemistry Catalysis Ruthenium chemistry.chemical_compound chemistry Cascade reaction Selectivity
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201645150
Popis:	The first reverse regioselective intermolecular annulation of aryl substituted 2-acetylenic ketones with O-substituted N-hydroxybenzamides or acrylamides followed by tandem cyclization via ruthenium-catalyzed C–H activation, is reported. Excellent reverse selectivity of alkyne insertion was induced by the weak coordination between the carbonyl group and ruthenium complex. This highly efficient and practical reaction has a broad range of substrate scope with excellent functional-group tolerance. The tandem reaction provides a wide range of polycyclic products that have an indozilidine structural motif, and are found to potentially be synthetically and pharmaceutically valuable.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b3d251cbb0334c5ff093d15660540c5 https://doi.org/10.1002/chin.201645150 Zobrazit plný text záznamu Plný text