Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin

Autor:	Ben-qiang Deng, Tao Wu, Zhong-kui Wang, Suju Ding, Jing-hua Wang
Rok vydání:	2009
Předmět:	Messenger RNA Thymic stromal lymphopoietin Thymoma Regulatory T cell FOXP3 hemic and immune systems chemical and pharmacologic phenomena General Medicine Biology medicine.disease Myasthenia gravis medicine.anatomical_structure Immunology medicine Immunohistochemistry IL-2 receptor
Zdroj:	Journal of Medical Colleges of PLA. 24:50-55
ISSN:	1000-1948
DOI:	10.1016/s1000-1948(09)60017-4
Popis:	Objective To investigate the expression of both thymic regulatory T cells (CD4+ CD25+ Foxp3+ cells, Treg) and thymic stromal lymphopoietin (TSLP) in thymomas accompanying myasthenia gravis. Methods We used immunohistochemistry and real-time reverse trancription polymerase chain reaction (real-time RT-PCR) techniques to determine Foxp3+ Treg counts and the expression levels of Foxp3 mRNA and TSLP mRNA in thymomas of 23 MG patients and thymuses of 4 healthy controls. Results The CD4+ Foxp3+ nTreg (natural regulatory T cells) counts in thymomas were significantly lower than those in normal thymuses (P Conclusion The insufficient expression of Foxp3 in thymoma, which may be caused by decreased transcription of TSLP, may result in the reduction of Tregs and cause autoimmune disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1b38a47fe38bc525232224a762e951a2 https://doi.org/10.1016/s1000-1948(09)60017-4 Zobrazit plný text záznamu Full Text from ScienceDirect