Do We Need Broad Immunological Work-Up in All Patients with CIS? (P02.153)
| Autor: | Vanja Posavec, Ana Boskovic, Ivan Adamec, Marin Radmilović, Mateja Bošković, Mario Habek, Tereza Gabelić |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Lupus anticoagulant Clinically isolated syndrome Anti-nuclear antibody business.industry Multiple sclerosis medicine.disease Anti-thyroid autoantibodies Internal medicine medicine Clinical significance Neurology (clinical) Differential diagnosis business |
| Zdroj: | Neurology. 78:P02.153-P02.153 |
| ISSN: | 1526-632X 0028-3878 2008-2010 |
| DOI: | 10.1212/wnl.78.1_meetingabstracts.p02.153 |
| Popis: | Objective: The aim of this study was to determine the prevalence of altered immunological tests and their clinical significance in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). Background The special problem in the differential diagnosis of MS represents various laboratory tests that are often used as a screening tool for possible MS mimics. Design/Methods: The information was gathered from medical records of patients hospitalized in the Referral Center for Demyelinating Diseases in the 2008-2010 period. All patients had ANA, ENA profile, ANCA, aCl IgG and IgM, lupus anticoagulant, C3, C4, CH50, anti-TPO, AST and RF antibodies tested. Results: From 726 patients with CIS that were reviewed, the complete battery of immunological tests was performed in 418 of them (57.6%), representing our cohort. Altered tests were found in 235 patients (56.2%); 73 (17.4%) had positive antinuclear antibodies, 14 (3.3%) had positive ENA, 47 (11.2%) had positive aCI IgG, 83 (19.8%) had positive aCI IgM, and 13 (3.1%) had anti TPO antibodies. We found no correlation between ANA, aCl IgG or IgM positivity (ANA vs aCL IgG p=0,554; ANA vs aCL IgM p=0,19; aCL IgG vs aCL IgM, p=0,155). None of the patients had any clinical manifestations other than MS symptoms. Conclusions: These results indicate that significant number of patients with CIS have altered immunological tests but nevertheless none of them had clinical expression of any other autoimmune disease making them clinically insignificant. In conclusion there is no need to perform expensive immunological work-up in all patients with CIS, unless signs or symptoms indicating other autoimmune disease. Disclosure: Dr. Adamec has nothing to disclose. Dr. Boskovic has nothing to disclose. Dr. Boskovic has nothing to disclose. Dr. Posavec has nothing to disclose. Dr. Radmilovic has nothing to disclose. Dr. Gabelic has nothing to disclose. Dr. Habek has nothing to disclose. |
| Databáze: | OpenAIRE |
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