| Autor: | A Kh Urazaev, A. I. Malomuzh, R A Khairova, N V Naumenko |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Membrane potential
Denervation medicine.medical_specialty Chemistry Skeletal muscle General Medicine Pirenzepine Resting potential General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Endocrinology Internal medicine Muscarinic acetylcholine receptor Oxotremorine medicine Acetylcholine medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 135:120-122 |
| ISSN: | 0007-4888 |
| DOI: | 10.1023/a:1023899210383 |
| Popis: | Denervation of rat phrenic muscle or block of NO-synthase in vivo increased the cross-section area of muscle fibers and decreased membrane resting potential. Oxotremorine prevented the development of denervation-induced or denervation-like (i.e. induced by NO-synthase blockade) membrane depolarization and increase of the cross-sectional area of muscle fibers. Pirenzepine abolished the effects of oxotremorine. It was concluded that non-quantal acetylcholine can be involved in the regulation of skeletal muscle fiber volume via activation of M1 muscarinic receptors followed by NO synthesis. |
| Databáze: | OpenAIRE |
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