Effect of melatonin treatment on liver and thymus zinc levels in young and middle-aged rats
| Autor: | Deniz Sevinç, K. Gonca Akbulut, Güler Öztürk, Lale Afrasyap |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty chemistry.chemical_element Melatonin treatment Zinc Biology Biochemistry carbohydrates (lipids) Melatonin Pineal gland Subcutaneous injection Endocrinology Enzyme medicine.anatomical_structure chemistry hemic and lymphatic diseases Internal medicine medicine neoplasms medicine.drug |
| Zdroj: | The Journal of Trace Elements in Experimental Medicine. 17:75-80 |
| ISSN: | 0896-548X |
| DOI: | 10.1002/jtra.10055 |
| Popis: | Melatonin (MEL) is the main neurohormone of the pineal gland. Zinc (Zn) is an essential trace element that is required as a catalytic component for more than 200 enzymes. Both MEL and Zn are considered beneficial for anti-immunosenescence. Recent findings have shown that MEL can modulate Zn turnover. The aim of this study was to investigate the effect of MEL treatment on the tissue Zn levels in young (4 months) and middle-aged (14 months) rats. Male wistar rats received during 3 weeks subcutaneous injection of MEL (10 mg/kg). After 3 weeks, rats were decapitated and tissue samples were collected. Zn levels were measured by spectrophotometric assay. In conclusion, MEL decreased liver Zn levels both in young and middle-aged rats. In addition, Zn levels in young control group were significantly higher than middle-aged control group. However, MEL treatment increased thymus Zn levels in middle-aged group compared with the control. These findings indicate that tissue Zn levels are significantly affected by MEL treatment. J. Trace Elem. Exp. Med. 17:7580 |
| Databáze: | OpenAIRE |
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