Intrinsic Radiation Sensitivity: Cellular Signaling is the Key

Autor:	I. Szumiel
Rok vydání:	2008
Předmět:	Cell signaling Radiation Kinase DNA damage DNA repair Biophysics Context (language use) Biology Chromatin Cell biology chemistry.chemical_compound Radiation sensitivity chemistry Radiology Nuclear Medicine and imaging DNA
Zdroj:	Radiation Research. 169:249-258
ISSN:	1938-5404 0033-7587
DOI:	10.1667/rr1239.1
Popis:	Szumiel, I. Intrinsic Radiation Sensitivity: Cellular Signaling is the Key. Radiat. Res. 169, 249–258 (2008). The concept that the balance between DNA damage and repair determines intrinsic radiation sensitivity has dominated radiobiology for several decades. There is undeniably a cause– effect relationship between radiation-induced molecular alterations in the genomic DNA and cellular consequences. In the last decade, however, it has become obvious that the chromatin context affects the fate of damaged DNA and that cellular signaling is an important factor in defining intrinsic radiation sensitivity. Damaged DNA is the site of signal generation; however, alternative signaling at the plasma membrane is triggered: Reactive oxygen species (ROS) inactivate phosphatases and consequently cause activation of kinases localized at the plasma membrane; this includes ligand-independent activation of receptor kinases. Cells with an apparently functional DNA repair system may show increased radiation sensiti...
Databáze:	OpenAIRE
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