Clopidogrel – a Platelet Inhibitor which Inhibits Thrombogenesis in Non-Anticoagulated Human Blood Independently of the Blood Flow Conditions
| Autor: | Peter Kierulf, Dickinson Jp, R. M. Barstad, Kieffer G, Skjørten F, Kjell S. Sakariassen, Roald He |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
biology Chemistry Hematology Blood flow medicine.disease Clopidogrel Fibrin Collagen Type III Endocrinology Platelet degranulation Internal medicine medicine biology.protein Platelet cardiovascular diseases Platelet activation Thrombus circulatory and respiratory physiology medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 71:655-662 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1642499 |
| Popis: | SummaryThe goal of the present study was to investigate the effect of 7 and 14 days of daily oral administration of 75 mg clopidogrel on collagen-induced thrombogenesis in flowing non-anticoagulated human blood. Blood was drawn directly from an antecubital vein over immobilised collagen type III fibrils positioned in a parallel-plate perfusion chamber. The wall shear rates at the collagen surface were those characteristic for veins (100 s−1), and for medium sized (650 s−1) and moderately stenosed (2600 s−1) arteries.Clopidogrel ingestion reduced the thrombus volume significantly (p Thus, it appears that clopidogrel inhibits thrombus formation in human blood primarily by interfering with platelet-platelet binding and the inhibition is effective independently of the wall shear rate. |
| Databáze: | OpenAIRE |
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