Trace Amines and Behavior
| Autor: | E. P. Vinogradova, D. A. Zhukov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Tryptamine Chemistry Dopaminergic Tyramine Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure medicine Octopamine (neurotransmitter) Serotonin Receptor Molecular Biology Olfactory epithelium Neuroscience 030217 neurology & neurosurgery Trace amine-associated receptor |
| Zdroj: | Neurochemical Journal. 14:347-352 |
| ISSN: | 1819-7132 1819-7124 |
| Popis: | —Trace amines are similar in structure to catecholamines and serotonin of the central nervous system but are present at much lower concentrations. Trace amines such as tyramine, tryptamine, octopamine, and β-phenylethylamine, bind to highly specific receptors that have low affinity for catecholamines and serotonin. Several types of trace amine receptors have been identified. Trace amine-associated receptor 1 is localized in the prefrontal cortex and limbic structures. Localization of the other types of receptors is different. In particular, trace amine-associated receptor 5 is localized in the olfactory epithelium and structures of the olfactory brain. By interaction with dopaminergic and other neurotransmitter systems of the CNS, trace amines are involved in the regulation of many behavioral forms. In simplistic terms, we can talk about the functional antagonism of trace amines and the dopaminergic system. Trace amines are considered as promising antipsychotics, which is evidenced by the results of studies in animal models of schizophrenia. |
| Databáze: | OpenAIRE |
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