Biotherapies of rabbit serum modulate the immune response and decrease parasite load in mice infected with Trypanosoma cruzi
| Autor: | Denise Lessa Aleixo, Fabiana Nabarro Ferraz, Larissa Ciupa, Wander Rogério Pavanelli, Franciele Karina da Veiga, Silvana Marques de Araújo, Benício Alves de Abreu Filho, Suelen Santos da Silva, Ivete Conchon-Costa |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Th2 response Health Toxicology and Mutagenesis Biomedical Engineering Inflammation Parasitemia Biology Parasite load General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Animal model Immune system Artificial Intelligence parasitic diseases medicine General Pharmacology Toxicology and Pharmaceutics Trypanosoma cruzi General Immunology and Microbiology General Neuroscience General Medicine medicine.disease biology.organism_classification 030205 complementary & alternative medicine 030104 developmental biology Immunology Th1 response medicine.symptom General Agricultural and Biological Sciences |
| Zdroj: | Journal of Applied Biomedicine. 14:187-197 |
| ISSN: | 1214-0287 1214-021X |
| Popis: | The use of biotherapies as intervention in murine infection with Trypanosoma cruzi is a possible means to understand the effects of these highly diluted medications. This study evaluated the effects of biotherapies that were prepared from rabbit serum uninfected (BSNI13c group) and chronically infected with Y strain of T. cruzi (BSI13c group), dynamization 13c, in mice experimentally infected. Parasitological, histopathological, and immunological parameters were evaluated. BSNI13c group exhibited the best outcome, including decreases in parasitemia and parasite load/inflammation in the heart, with pronounced Th1 response on days 8 and 12 after infection (a.i.) that was attributable to decrease in IL-4 concentrations, with no increases in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. In contrast, BSI13c group did not exhibit alterations in parasitemia but a significant decrease in parasite load/inflammation in the heart, with pronounced Th2 response on day 12 a.i. that was attributable to increase in IL-4 concentrations, with no changes in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. This study suggest that biotherapies that were prepared from rabbit serum uninfected and chronically infected with T. cruzi differentially modulate the immune system in mice infected with this protozoan, providing evidence of the actions of these medications. |
| Databáze: | OpenAIRE |
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