Citrinin-induced mitochondrial permeability transition
| Autor: | Eva Gunilla Skare Carnieri, Maria Benigna M. Oliveira, Eneida Janiscki Da Lozzo |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Ruthenium red
animal structures biology Chemistry Health Toxicology and Mutagenesis food and beverages General Medicine Mitochondrion Toxicology Biochemistry Dithiothreitol Citrinin chemistry.chemical_compound Mitochondrial permeability transition pore Catalase Cyclosporin a biology.protein Molecular Medicine Efflux Molecular Biology |
| Zdroj: | Journal of Biochemical and Molecular Toxicology. 12:291-297 |
| ISSN: | 1099-0461 1095-6670 |
| DOI: | 10.1002/(sici)1099-0461(1998)12:5<291::aid-jbt5>3.0.co;2-g |
| Popis: | The effects of mycotoxin citrinin on Ca2+ efflux and membrane permeabilization were studied in isolated rat liver mitochondria. The efflux rate observed when in presence of ruthenium red was higher when citrinin was added. Swelling experiments demonstrated Ca2+-dependent membrane permeabilization by citrinin. Catalase, butylhydroxitoluene (BHT), and dithiothreitol (DTT) did not protect swelling caused by Ca2+ plus citrinin. The protection conferred by ATP–Mg2+ and cyclosporin A in the latter experiments are strong indications of pore formation. These results suggest that citrinin can induce permeability transition by a mechanism that does not involve oxidative damage. © 1998 John Wiley & Sons, Inc. J Biochem Toxicol 12: 291–297, 1998 |
| Databáze: | OpenAIRE |
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