| Autor: |
Jitka Malčíková, Martin Brejcha, Michalis Iskas, Sarah Mould, Kristina Stepanovska, Zadie Davis, Chrysoula Belessi, David Oscier, Sharron Glide, Šárka Pospíšilová, Kostas Stamatopoulos, Karla Plevová, Achilles Anagnostopoulos, Panagiotis Baliakas, Florence Nguyen-Khac, Frederic Davi, Anne Gardiner, Anastasia Athanasiadou |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
American Journal of Hematology. 89:249-255 |
| ISSN: |
0361-8609 |
| Popis: |
The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry 1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (3 aberrations) was detected in 157 cases and significantly (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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