Behavior of POP-calcium carbonate hydrogel as bone substitute with controlled release capability: A study in rat
| Autor: | John A. Jansen, Ika Dewi Ana, Anne Handrini Dewi, Joop G.C. Wolke |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Bone substitute medicine.medical_treatment Metals and Alloys Biomedical Engineering chemistry.chemical_element Biomaterial Calcium Bone grafting Controlled release Biomaterials chemistry.chemical_compound Calcium carbonate chemistry In vivo Ceramics and Composites medicine Bone formation Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part A. 103:3273-3283 |
| ISSN: | 1549-3296 |
| Popis: | Gypsum or calcium sulfate (CS) or plaster of Paris (POP) is considered as a fast degradable material that usually resorbs before the bone defect area is completely filled by new bone. In this study, the incorporation of CaCO3 hydrogel into POP in different compositions was proposed to enhance the bone biological activity of POP and to decrease its degradability. The mechanical and degradation properties of the various materials were characterized by in vitro analysis. Subsequently, the materials were inserted into cylindrically sized bone defects as created into the femoral condyle of rats and left in situ for 1, 4, and 8 weeks. Histological analysis of the retrieved specimens indicated that the addition of CaCO3 hydrogel into POP increased bone formation, angiogenesis and collagen density and resulted into faster bone formation and maturation. It was also confirmed that the degradation rate of the POP decreased by the addition of CaCO3 hydrogel. The in vivo findings did corroborate with the in vitro analysis. In conclusion, the incorporation of CaCO3 hydrogel provides a promising technology to improve the properties of POP, the oldest biomaterial used for bone grafting. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3273–3283, 2015. |
| Databáze: | OpenAIRE |
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