Impact of Calcium and Two Doses of Vitamin D on Bone Metabolism in the Elderly: A Randomized Controlled Trial
| Autor: | Moustapha Kassem, Asma Arabi, Georges Halaby, Rafic Baddoura, Ravinder J. Singh, Darina Bassil, Sima L. Sharara, Maha Hoteit, Ziyad Mahfoud, Rose T. Daher, Robert H. Habib, Maya Rahme, Karim El Ferkh, Ghada El-Hajj Fuleihan |
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| Rok vydání: | 2017 |
| Předmět: |
Vitamin
medicine.medical_specialty Endocrinology Diabetes and Metabolism Elemental calcium 030209 endocrinology & metabolism Overweight Gastroenterology law.invention Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Vitamin D and neurology Orthopedics and Sports Medicine 030212 general & internal medicine Adverse effect business.industry Endocrinology chemistry medicine.symptom business Body mass index |
| Zdroj: | Journal of Bone and Mineral Research. 32:1486-1495 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.3122 |
| Popis: | The optimal dose of vitamin D to optimize bone metabolism in the elderly is unclear. We tested the hypothesis that vitamin D, at a dose higher than recommended by the Institute of Medicine (IOM), has a beneficial effect on bone remodeling and mass. In this double-blind trial we randomized 257 overweight elderly subjects to receive 1000 mg of elemental calcium citrate/day, and the daily equivalent of 3750 IU/day or 600 IU/day of vitamin D3 for 1 year. The subjects' mean age was 71 ± 4 years, body mass index 30 ± 4 kg/m2 , 55% were women, and 222 completed the 12-month follow-up. Mean serum 25 hydroxyvitamin D (25OHD) was 20 ng/mL, and rose to 26 ng/mL in the low-dose arm, and 36 ng/mL in the high-dose arm, at 1 year (p 76 pg/mL showed a trend for higher BMD increments at all skeletal sites, in the high-dose group, that reached significance at the hip. Adverse events were comparable in the two study arms. This controlled trial shows little additional benefit in vitamin D supplementation at a dose exceeding the IOM recommendation of 600 IU/day on BMD and bone markers, in overweight elderly individuals. © 2017 American Society for Bone and Mineral Research. |
| Databáze: | OpenAIRE |
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