Preliminary Evidence That GnRH Has the Properties of a Growth Hormone-Releasing Factor In Vivo in the Rat
| Autor: | Stephanie R. Goodman, Raymond F. Aten, Ervin E. Jones, Harold R. Behrman, Gabriele Rossi, Alan S. Penzias, Fayek N. Shamma |
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| Rok vydání: | 1995 |
| Předmět: |
Estrous cycle
endocrine system medicine.medical_specialty 030219 obstetrics & reproductive medicine Chemistry Obstetrics and Gynecology Gonadotropin-releasing hormone Growth hormone–releasing hormone Apomorphine 03 medical and health sciences 0302 clinical medicine Endocrinology Somatostatin In vivo Internal medicine medicine Luteinizing hormone hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug Hormone |
| Zdroj: | Journal of the Society for Gynecologic Investigation. 2:623-629 |
| ISSN: | 1071-5576 |
| Popis: | We investigated whether GnRH has the properties of a growth hormone-releasing factor in vivo in a mammalian species. Sexually mature female Sprague-Dawley rats were prepared for in vivo dynamic hormone testing. The rats were assigned to one of four groups: I) GnRH, II) apomorphine and GnRH, III) somatostatin and GnRH, or IV) saline control. Blood samples were drawn at 0, 30, 60, 90, and 120 minutes after treatment. Growth hormone (GH) and LH were measured by radioimmunoassay. Results were analyzed using repeated-measures analysis of variance, Student test, and comparisons of the area under the curve where appropriate. Gonadotropin-releasing hormone caused a marked rise in both GH and LH levels as a junction of time. Apomorphine caused a significant blunting of the LH response to GnRH but did not blunt the GnRH-induced rise in GH. Somatostatin blocked the GnRH-induced rise in GH but did not block the increase in LH. In saline-treated controls, neither the GH nor LH levels exhibited a statistically significant variance over the 2-hour test period. Gonadotropin-releasing hormone appears to have the properties of a growth hormone-releasing factor. |
| Databáze: | OpenAIRE |
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