Population and molecular genetics of susceptibility to intracellular pathogens
| Autor: | E. Skamene, E. Schurr, Jinxin Hu, D. Malo |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Genetics
Candidate gene medicine.medical_specialty education.field_of_study biology Positional cloning Intracellular parasite Population Leishmania donovani Bioengineering Locus (genetics) biology.organism_classification Molecular genetics medicine Animal Science and Zoology education Gene Biotechnology |
| Zdroj: | Animal Biotechnology. 5:173-182 |
| ISSN: | 1532-2378 1049-5398 |
| Popis: | In the mouse, innate resistance to infection with certain species of Mycobacteria, Salmonella typhimurium and Leishmania donovani is controlled by the expression of a single dominant chromosome 1 gene, designated Bcg. The major effect of the Beg locus is the modulation of the growth rate of these pathogens in cells of the reticuloendothelial tissues during early infection. Using a positional cloning approach, a novel gene designated Nramp has recently been identified as a candidate gene for Bcg. Comparison of linkage and physical maps of mouse, human, bovine and chicken chromosomes indicates that a large cluster of genes in the proximal portion of mouse chromosome 1 is conserved among a variety of species. This has opened up the possibilities of testing the candidacy of Nramp for host resistance and susceptibility to human tuberculosis and leprosy, chicken salmonellosis and cow brucellosis. |
| Databáze: | OpenAIRE |
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