Microwave-induced and pharmacological suppression of somatic pain under conditions of the formalin test in mice

Autor: E. N. Gura, E. M. Gonchar
Rok vydání: 2006
Předmět:
Zdroj: Neurophysiology. 38:39-44
ISSN: 1573-9007
0090-2977
DOI: 10.1007/s11062-006-0024-z
Popis: We examined pain-related behavioral reactions and non-pain behavioral manifestations in mice under conditions of the formalin test. Levels of analgesia induced by i.p. injections of analgin, microwave irradiation of an antinociceptive acupuncture point (AP), E-36, or combined application of the above factors were measured. The duration of the pain behavioral reaction (licking of the injured limb) decreased due to irradiation of the AP with microwaves and to injection of 8.3 mg/kg analgin by 24.3% and 53.8%, on average, respectively. Combination of injection of analgin in a smaller dose (4.2 mg/kg) and microwave irradiation of the AP suppressed manifestations of the pain behavioral reaction by 43.4%. Thus, combination of pharmacologically induced analgesia with the action of microwaves on the antinociceptive AP allows one to significantly decrease the doses of analgesic preparations necessary to provide a full-level analgesic effect; in such a way, side effects of the respective drugs can be weakened.
Databáze: OpenAIRE
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