Temporal Trends of Women Enrollment in Major Cardiovascular Randomized Clinical Trials
| Autor: | Shaun G. Goodman, Andreas Laupacis, Dennis T. Ko, Muhammad Mamdani, Andrew T. Yan, Inna Y. Gong, Gerald Lebovic, Sammy H. Ali, Nigel S. Tan |
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| Rok vydání: | 2019 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Future studies business.industry Population MEDLINE Disease 030204 cardiovascular system & hematology Design characteristics law.invention Clinical trial 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Intervention Type Medicine 030212 general & internal medicine Cardiology and Cardiovascular Medicine business education |
| Zdroj: | Canadian Journal of Cardiology. 35:653-660 |
| ISSN: | 0828-282X |
| Popis: | Background Although it is known that women do not participate in trials as frequently as men, there are limited recent data examining how women recruitment has changed over time. Methods We conducted MEDLINE search using a validated strategy for randomized trials published in New England Journal of Medicine, Lancet, and Journal of the American Medical Association between 1986 and 2015, and included trials evaluating pharmacologic or nonpharmacologic therapies. We abstracted data on demographics, intervention type, clinical indication, and trial design characteristics, and examined their relationships with women enrollment. Results In total, 598 trials met inclusion criteria. Women enrollment increased significantly over time (21% between 1986 and 1990 to 33% between 2011 and 2015; Pfor trend Conclusions Although enrollment of women has increased over time, it remains lower than the relative proportion in the disease population. Future studies should elucidate the reasons for persistent under-representation of women in clinical trials. |
| Databáze: | OpenAIRE |
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